A team of researchers at the Indian Institute of Technology (IIT) Guwahati has designed a non-sticking, non-wetting liquid marble that floats in water and releases its contents in a pre-programmed time, ANI reported on Tuesday, April 25.
Researchers at IIT Guwahati have developed these liquid marbles using nano clay that can be pre-programmed for drug delivery and cascade chemical reactions, explained one of the researchers.
One of the researchers said, “Conventionally for treating any disease, we take medicines in the form of tablets, capsules, syrups, ointments, etc. A controlled drug delivery system is a more efficient technique to deliver the required dose at the specific site gradually over the desired period of time. Loading and release of the drug in its soluble form is another important aspect which can be achieved with this liquid marble.”
The researcher further added that, unlike normal droplets, a liquid marble is a non-sticking, non-wetting droplet.
“It is created by wrapping a droplet with fine hydrophobic particles i.e., water-repelling particles. When put in a water pool, liquid marbles can be rolled, squeezed, and even float without spilling. In nature gall-forming aphids create liquid marbles by coating the honeydew they secrete in a powdery wax,” they explained.
A research team from the IIT Guwahati led by Dr. Uttam Manna, Associate Professor, Department of Chemistry and Centre for Nanotechnology, IIT Guwahati has used the liquid marbles approach for the controlled release of drugs and programmed chemical reaction.
Explaining the use of this technology, the researchers added, “Liquid marbles are soft spherical solids that can be used for multiple applications by replacing the liquid inside them. Some examples are in the field of sensor platforms, soft robotics, healing agents, biosystems, etc.”
The details on the formation of the liquid marbles and their programmed drug release application have been published in the journal ‘Advanced Functional Materials’ and the paper has been co-authored by Nishanta Barman, Arpita Shome, Saurav Kumar, Priyam Mondal, Karan Jain, Mizuki Tenjimbayashi and Dr Uttam Manna.
Explaining the research challenge Dr Manna said, "Release of drugs from a liquid marble in response to a stimulus for instance light, temperature, electricity has been reported earlier. But the time-programmed release was not yet achieved. We have chemically modified the lifetime of a floating liquid marble on a water pool… The nano clay marbles were made of a shell of nano clay that holds the liquid. To programme the marbles for timed release of the content, the researchers modified the nano clay with chemical groups that were either water-loving or water-hating"
Dr Manna further explained, "A water droplet was laid on a powder bed consisting of hydrophilic and hydrophobic nano clay powders. The properties and stability of the liquid marbles changed according to the relative amounts of the water-hating and water-loving groups on the nano clay surface."
