ADVERTISEMENT
site_logo
  • Campus
  • Happening
  • Opinion
  • People
  • News
  • #BeInspired
  • Careers
  • 40 under 40
  • Exams
  • What The FAQ
  • Videos
    • Straight Up
    • Odisha Literary Festival 2020
    • Campus Convo
    • Careers After Corona
    • Express Expressions
    • Q&A With Prabhu Chawla
    • ThinkEdu Awards 2020
  • edex_worksEDEXWORKS
ADVERTISEMENT
health

Published: 11th April 2020     

Researchers in the US develop computer model that predicts how drugs affect heart rhythm

Heart arrhythmia, also known as irregular heartbeat or cardiac dysrhythmia, is a group of conditions where the heartbeat is irregular, too slow, or too fast

Edex Live
Edex Live
f_icon t_icon i_icon l_icon koo_icon whatsapp_icon email_icon

Share Via Email

586307562_640x360

Image for representational purpose only (Pixabay)

Researchers have developed a computer model to screen drugs for unintended cardiac side effects, especially arrhythmia risk.

Heart arrhythmia, also known as irregular heartbeat or cardiac dysrhythmia, is a group of conditions where the heartbeat is irregular, too slow, or too fast.

"One main reason for a drug being removed from the market is potentially life-threatening arrhythmias. Even drugs developed to treat arrhythmia have ended up actually causing them," said study researcher Colleen E Clancy, Professor at the University of California-Davis in the US.

The problem, according to Clancy, is that there is no easy way to preview how a drug interacts with hERG-encoded potassium channels essential to normal heart rhythm.

"So far there has been no surefire way to determine which drugs will be therapeutic and which will harmful," Clancy said.

"What we have shown is that we can now make this determination starting from the chemical structure of a drug and then predicting its impact on the heart rhythm," Clancy added.

Using a drug's chemical formula, the computer model reveals how that drug specifically interacts with hERG channels as well as cardiac cells and tissue.

The outcomes can then be validated with comparisons to clinical data from electrocardiogram (ECG) results of patients.

For the study, published in the journal Circulation Research, the researchers validated the model with ECGs of patients taking two drugs known to interact with hERG channels -- one with a strong safety profile and another known to increase arrhythmias.

The results proved the accuracy of the model.

Clancy envisions the model will offer an essential pre-market test of cardiac drug safety. That test could ultimately be used for other organ systems such as the liver and brain.

"Every new drug needs to go through a screening for cardiac toxicity, and this could be an important first step to suggesting harm or safety before moving on to more expensive and extensive testing," Clancy said.

telegram
TAGS
health

O
P
E
N

ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT
telegram
ADVERTISEMENT
Write to us!

If you have campus news, views, works of art, photos or just want to reach out to us, just drop us a line.

newsletter_icon
Mailbox
edexlive@gmail.com
fb_icon
Facebook
twitter_icon
Twitter
insta_icon
Instagram
ADVERTISEMENT
Facebook
ADVERTISEMENT
Tweets by Xpress_edex
ADVERTISEMENT
ADVERTISEMENT

FOLLOW US

Copyright - edexlive.com 2021

The New Indian Express | Dinamani | Kannada Prabha | Samakalika Malayalam | Indulgexpress | Cinema Express | Event Xpress

Contact Us | About Us | Privacy Policy | Terms of Use | Advertise With Us

Home | Live Now | Live Story | Campus Trip | Coach Calling | Live Take